JERUSALEM (AP) — The Latest on confrontations between Israelis and Palestinians as Israel signals a widening military campaign:

GAZA CITY, Gaza Strip — The Gaza Health Ministry says the death toll from Israeli airstrikes on Gaza has climbed to 43, including 13 children and three women.

It says nearly 300 Palestinians in the territory have been wounded in the strikes.

The strikes began Monday as Palestinians launched a barrage of rockets into Israel. The worst fighting since the 2014 Gaza war was ignited by clashes in Jerusalem in recent weeks between Palestinian protesters and Israeli police focused on the Al-Aqsa Mosque compound, a site sacred to Jews and Muslims.

The head of Israel’s emergency service also says one person has been killed and one seriously wounded by an anti-tank missile fired from the Gaza Strip.

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JERUSALEM — The head of Israel’s emergency service says one person has been killed and one seriously wounded by an anti-tank missile fired from the Gaza Strip.

Eli Bein of Magen David Adom said the Wednesday morning attack hit a jeep. Israeli media reported the assault Wednesday morning.

The attack came after a night of deadly exchanges of rocket fire between Israel and Palestinians. It was an abrupt escalation of weeks of tension with roots in disputed Jerusalem.